Complications ensue when an overworked couple decides to hire a "wife" — someone who can run the household for them with complete autonomy — but she's a little too attractive for comfort.
| Actor | Role |
|---|---|
 Bill BixbyJeff Hamilton | Jeff Hamilton |
 Paula PrentissBarbara Hamilton | Barbara Hamilton |
 Valerie PerrineJennifer Allen | Jennifer Allen |
 Myrna LoyBarbara's Mother | Barbara's Mother |
 Robert GouletRandy Perkins | Randy Perkins |
 Nanette FabrayMarion Randolph | Marion Randolph |
 Larry StorchDavid | David |
| MMia BendixsenChristy Hamilton | Christy Hamilton |
| DDana LauritaMindy Hamilton | Mindy Hamilton |
 Penny MarshallPaula | Paula |
 Dwan SmithGinger | Ginger |
 Carmen ZapataMaria | Maria |
 Ruth McDevittMrs. Flanagan | Mrs. Flanagan |
 Bert HollandMr. Kaplan | Mr. Kaplan |
 Shirley MitchellEmployment Clerk | Employment Clerk |
| RRalph O'HaraHotel Clerk | Hotel Clerk |
 Tim HaldemanBellboy | Bellboy |
 Helen KleebMiss Robbins | Miss Robbins |