 Jean HersholtDr. John Luke | Dr. John Luke |
| YYvonne DionneYvonne, a Wyatt Quintuplet | Yvonne, a Wyatt Quintuplet |
| AAnnette DionneAnnette, a Wyatt Quintuplet | Annette, a Wyatt Quintuplet |
| CCécile DionneCécile, a Wyatt Quintuplet | Cécile, a Wyatt Quintuplet |
| ÉÉmilie DionneÉmilie, a Wyatt Quintuplet | Émilie, a Wyatt Quintuplet |
| MMarie DionneMarie, a Wyatt Quintuplet | Marie, a Wyatt Quintuplet |
 June LangMary MacKenzie | Mary MacKenzie |
 Slim SummervilleConstable Jim Ogden | Constable Jim Ogden |
 Michael WhalenTony Luke | Tony Luke |
 Dorothy PetersonNurse Katherine Kennedy | Nurse Katherine Kennedy |
 Robert BarratMacKenzie | MacKenzie |
 Jane DarwellMrs. Graham | Mrs. Graham |
 John QualenAsa Wyatt | Asa Wyatt |
 Frank ReicherDr. Paul Luke | Dr. Paul Luke |
 Montagu LoveSir Basil Crawford | Sir Basil Crawford |
 David TorrenceGovernor General | Governor General |
 George ChandlerGreasy | Greasy |
 Helen Jerome EddyMrs. Ogden | Mrs. Ogden |
 Aileen CarlyleMrs. Wyatt | Mrs. Wyatt |
 George MeekerDr. Wilson | Dr. Wilson |
 J. Anthony HughesMike | Mike |
 William BenedictThe Gawker | The Gawker |
 Stanley BlystoneLogger (uncredited) | Logger (uncredited) |
 Sven Hugo BorgLogger (uncredited) | Logger (uncredited) |
 Harry C. BradleyClergyman (uncredited) | Clergyman (uncredited) |
| RRichard CarlyleBishop (uncredited) | Bishop (uncredited) |
 Horace B. CarpenterTownsman (uncredited) | Townsman (uncredited) |
 Mary CarrWoman with Baby Clothes (uncredited) | Woman with Baby Clothes (uncredited) |
| WWilliam ConlonPeg-leg Walter (uncredited) | Peg-leg Walter (uncredited) |
 Harry CordingLogger (uncredited) | Logger (uncredited) |
