This was Theda Bara's third starring film, and the first which she carried all on her own, with no other name actors in the cast. Based on the Alexander Dumas story, The Clemenceau Case involves Iza, a vampire-wife (Bara), whose wicked ways scandalize her husband, Pierre (William E. Shay).
| Actor | Role |
|---|---|
 Theda BaraIza | Iza |
 William E. ShayPierre Clemenceau | Pierre Clemenceau |
| MMrs. Allen WalkerMarie Clemenceau | Marie Clemenceau |
 Stuart HolmesConstantin Ritz | Constantin Ritz |
 Jane LeeJanet | Janet |
 Saba RaleighCountess Dobronowska (as Mrs. Cecil Raleigh) | Countess Dobronowska (as Mrs. Cecil Raleigh) |
| FFrank GoldsmithDuke Sergius | Duke Sergius |
| SSidney ShieldsMadame Ritz | Madame Ritz |