 Bill HaderThe Cat in the Hat (voice) | The Cat in the Hat (voice) |
 Xochitl GomezGabby (voice) | Gabby (voice) |
 Tiago MartinezSebastian (voice) | Sebastian (voice) |
 Matt BerryWaffles (voice) | Waffles (voice) |
 Quinta BrunsonSherrie from HR (voice) | Sherrie from HR (voice) |
 Bowen YangGary (voice) | Gary (voice) |
 America FerreraMom (Carmen) (voice) | Mom (Carmen) (voice) |
 Paula PellPatty (voice) | Patty (voice) |
 Tituss BurgessThe Psychic Narwhal (voice) | The Psychic Narwhal (voice) |
 Giancarlo EspositoMr. Hoogeboom (voice) | Mr. Hoogeboom (voice) |
| RRyan GaffneyPig in a Wig (voice) | Pig in a Wig (voice) |
| AAsha MarieRosie (voice) | Rosie (voice) |
| MMayabella Sage MccrillisSally (voice) | Sally (voice) |
 Johnny HaemmerleDick (voice) | Dick (voice) |
 Robin ÅkerstrandAdditional Voice | Additional Voice |
 Eric BauzaAdditional Voice | Additional Voice |
 David KayeAdditional Voice | Additional Voice |
 Jim MeskimenAdditional Voice | Additional Voice |
| KKasur MohammedAdditional Voice | Additional Voice |
| DDan MolinaAdditional Voice | Additional Voice |
 Dannah Feinglass PhirmanAdditional Voice (as Dannah Phirman) | Additional Voice (as Dannah Phirman) |
| EEric WentzAdditional Voice | Additional Voice |
