The evil mastermind Fu Manchu plots his latest scheme to basically freeze over the Earth's oceans with his diabolical new device. Opposing him is his arch-nemesis, Interpol's very British Nayland Smith.
| Actor | Role |
|---|---|
 Christopher LeeDr. Fu Man Chu | Dr. Fu Man Chu |
 Richard GreeneNayland Smith | Nayland Smith |
 Howard Marion-CrawfordDr. Petrie | Dr. Petrie |
 Tsai ChinLin Tang | Lin Tang |
 Günther StollCurt | Curt |
 Rosalba NeriLisa | Lisa |
 Maria PerschyMarie | Marie |
 José Manuel MartínOmar Pashu | Omar Pashu |
| WWerner AbrolatMelnik | Melnik |
 Jesús FrancoInsp. Ahmet | Insp. Ahmet |
 Herbert FuxGoverner | Governer |
 Mike BrendelNot listed | Not listed |
 Osvaldo GenazzaniNot listed | Not listed |
 Gustavo ReNot listed | Not listed |
| GGene ReyesNot listed | Not listed |
| MMoisés Augusto RochaNot listed | Not listed |