Passengers on a European train have been exposed to a deadly disease, and nobody will let them off the train.
| Actor | Role |
|---|---|
 Sophia LorenJennifer Rispoli Chamberlain | Jennifer Rispoli Chamberlain |
 Richard HarrisDr. Jonathan Chamberlain | Dr. Jonathan Chamberlain |
 Martin SheenRobby Navarro | Robby Navarro |
 O. J. SimpsonHaley | Haley |
 Ava GardnerNicole Dressler | Nicole Dressler |
 Burt LancasterCol. Stephen Mackenzie | Col. Stephen Mackenzie |
 Lionel StanderMax, the Train Conductor | Max, the Train Conductor |
 Ann TurkelSusan | Susan |
 Ingrid ThulinDr. Elena Stradner | Dr. Elena Stradner |
 Lee StrasbergHerman Kaplan | Herman Kaplan |
 Lou CastelSwedish Terrorist | Swedish Terrorist |
 John Phillip LawMajor Stark | Major Stark |
 Ray LovelockTom | Tom |
 Alida ValliMrs. Chadwick | Mrs. Chadwick |
 Stefano PatriziTerrorist | Terrorist |
 Thomas HunterCaptain Scott | Captain Scott |
| AAngela GoodwinNun | Nun |
 Carlo De MejoFaux Patient | Faux Patient |
 John P. DulaneyHarmonica Player | Harmonica Player |
 Fausta AvelliSweets | Sweets |