The Caribbean Mystery is a remake of Mr. Moto on Danger Island (1939)-which in turn was a remake of Murder in Trinidad. James Dunn stars as Mr. Smith, a Columbo-like Brooklyn detective who pops up on a tropical island to track down some missing geologists.
| Actor | Role |
|---|---|
 James DunnMr. Smith | Mr. Smith |
 Sheila RyanMrs. Jean Gilbert | Mrs. Jean Gilbert |
 Edward RyanGerald McCracken Jr. | Gerald McCracken Jr. |
| JJackie PaleyLinda Lane | Linda Lane |
 Reed HadleyDr. Rene Marcel | Dr. Rene Marcel |
 Roy RobertsCapt. Van den Bark | Capt. Van den Bark |
 Robert ShawLt. Bowman Hall | Lt. Bowman Hall |
| DDaral HudsonHartshorn | Hartshorn |
 William ForrestCol. Lane | Col. Lane |
 Roy GordonGov. Gerald McCracken Sr. | Gov. Gerald McCracken Sr. |
 Virginia WalkerAdelaide Marcel | Adelaide Marcel |