The continuing adventures of Henry, Jessie, Violet, and Benny as they spend the summer on their grandfather's private island.
| Actor | Role |
|---|---|
 Joey KingJessie (voice) | Jessie (voice) |
 Dane DeHaanJohn Joseph Alden (voice) | John Joseph Alden (voice) |
 Gil BirminghamNot listed | Not listed |
 J.K. SimmonsDr. Moore (voice) | Dr. Moore (voice) |
 Talitha Eliana BatemanViolet (voice) | Violet (voice) |
 Martin SheenJames Alden (voice) | James Alden (voice) |
 Griffin GluckHenry | Henry |
 Stephen StantonCaptain Daniel (voice) | Captain Daniel (voice) |
 Carter SandBenny (voice) | Benny (voice) |
 Davis PakMike (voice) | Mike (voice) |