Follows Jean Blake as she takes on the mantle of her husband, police surgeon Lucien Blake, as a solver of mysteries following his disappearance 18 months after their marriage.
| Actor | Role |
|---|---|
 Nadine GarnerJean Blake | Jean Blake |
 Joel TobeckChief Superintendent Matthew Lawson | Chief Superintendent Matthew Lawson |
 Belinda McCloryDoctor Alice Harvey | Doctor Alice Harvey |
| TTom WrenMartin Carver | Martin Carver |
 Emma AnnandAmy Parks | Amy Parks |
 Joshua OrpinConstable Peter Crowe | Constable Peter Crowe |
 David WhiteleyBill Hobart | Bill Hobart |
 Gyton GrantleyDon Roper | Don Roper |
 Ian RooneyCec Drury | Cec Drury |
 Julie NihillMaggie Butson | Maggie Butson |
 Lara SchwerdtBarbara Roper | Barbara Roper |
 Finn Scicluna-O'PreyGeoffrey Roper | Geoffrey Roper |
 Alan BroughSteve Whelan | Steve Whelan |
 Xavier GouaultConsoling Man | Consoling Man |
 Gabriel EganRussell Payton-Smith | Russell Payton-Smith |
| CChristopher BunworthBruce Beattie | Bruce Beattie |
| AAsleen MauthoorDiana Zurvas | Diana Zurvas |
| HHugo Iser-SmithRicky | Ricky |
 Matthew ConnellJack Stanton | Jack Stanton |
 Joshua FirmanEvan Butson | Evan Butson |
| SSebastian CourtJoe | Joe |
| NNicholas FoleyCouncil Speaker | Council Speaker |
| AAbbey AndrewsLivvie | Livvie |