Set in the world of New York City's elite private kindergartens, The Best and the Brightest centers on a fresh-faced young couple, Samantha and Jeff, who have only recently moved into town. The comedy centers on their dawning realization of the lengths they must go to in order to get their five-year-old daughter into school.
| Actor | Role |
|---|---|
 Neil Patrick HarrisJeff | Jeff |
 Bonnie SomervilleSamantha | Samantha |
 Peter SerafinowiczClark | Clark |
 Bridget ReganRobin | Robin |
 Jenna SternKatharine Heilmann | Katharine Heilmann |
 John HodgmanHenry | Henry |
 Kate MulgrewThe Player's Wife | The Player's Wife |
 Nina HodorukUpper East Side Mom | Upper East Side Mom |
 Michael ElianMiddle Eastern Bag Dealer | Middle Eastern Bag Dealer |
 Suzanne SavoyChapin Headmistress | Chapin Headmistress |
 Cornelia GuestSpence Mom | Spence Mom |
 Brea BeeGrace Church Mom | Grace Church Mom |
 Kelly Coffield ParkCindy Tanaka-Blumstein | Cindy Tanaka-Blumstein |
 Jos LaniadoLuis the Super | Luis the Super |
 Amy SedarisSue Lemon | Sue Lemon |
 Christopher McDonaldThe Player | The Player |
 Nina LisandrelloBianca | Bianca |