 William BendixGeorge Herman 'Babe' Ruth | George Herman 'Babe' Ruth |
 Claire TrevorClaire Hodgson Ruth | Claire Hodgson Ruth |
 Charles BickfordBrother Matthias | Brother Matthias |
 Sam LevenePhil Conrad | Phil Conrad |
 William FrawleyJack Dunn | Jack Dunn |
 Gertrude NiesenNightclub Singer | Nightclub Singer |
| FFred LightnerMiller Huggins | Miller Huggins |
 Stanley ClementsWestern Union Boy | Western Union Boy |
 Robert EllisBabe Ruth as a Boy (as Bobby Ellis) | Babe Ruth as a Boy (as Bobby Ellis) |
 Lloyd GoughGambler Dalton | Gambler Dalton |
 Matt BriggsColonel Jacob Ruppert | Colonel Jacob Ruppert |
 Paul CavanaghDr. Menzies | Dr. Menzies |
 Warren DouglasBoston Braves' Rookie | Boston Braves' Rookie |
 Pat FlahertyBill Carrigan, Red Sox Manager | Bill Carrigan, Red Sox Manager |
| MMark KoenigMark Koenig | Mark Koenig |
 Richard LaneBoston Braves' coach | Boston Braves' coach |
| ZZiggy SearsUmpire Ziggy Sears | Umpire Ziggy Sears |
| BBucky HarrisBucky Harris - Baseball Player | Bucky Harris - Baseball Player |
| HHarry WismerHarry Wismer - Sports Announcer | Harry Wismer - Sports Announcer |
 Mel AllenMel Allen - New York Yankees Radio Announcer | Mel Allen - New York Yankees Radio Announcer |
| HH.V. KaltenbornH. V. Kaltenborn - Radio News Commentator | H. V. Kaltenborn - Radio News Commentator |
 Knox ManningNarrator | Narrator |
 Al BainBarfly (uncredited) | Barfly (uncredited) |
| OOliver CrawfordReporter (uncredited) | Reporter (uncredited) |
