 Keanu ReevesNeo ("Kid's Story") (voice) | Neo ("Kid's Story") (voice) |
 Carrie-Anne MossTrinity ("Kid's Story" and "A Detective Story") (voice) | Trinity ("Kid's Story" and "A Detective Story") (voice) |
 Clayton WatsonThe Kid ("Kid's Story") (voice) | The Kid ("Kid's Story") (voice) |
 Pamela AdlonJue ("Final Flight of the Osiris") / Manabu ("Beyond") (voice) | Jue ("Final Flight of the Osiris") / Manabu ("Beyond") (voice) |
 Melinda ClarkeAlexa ("Matriculated") (voice) | Alexa ("Matriculated") (voice) |
 John DiMaggioCrew Man ("Final Flight of the Osiris") / Kaiser ("Program") (voice) | Crew Man ("Final Flight of the Osiris") / Kaiser ("Program") (voice) |
 Kevin Michael RichardsonThadeus ("Final Flight of Osiris") / Cop ("Kid's Story") / Agent #2 ("World Record") | Thadeus ("Final Flight of Osiris") / Cop ("Kid's Story") / Agent #2 ("World Record") |
 Tom KennyOperator ("Final Flight of Osiris") | Operator ("Final Flight of Osiris") |
 Rick GomezPilot ("Final Flight of Osiris") | Pilot ("Final Flight of Osiris") |
 Tara StrongCrew Woman ("Final Flight of Osiris") / Nurse ("World Record") / Misha ("Beyond") | Crew Woman ("Final Flight of Osiris") / Nurse ("World Record") / Misha ("Beyond") |
 Bette FordOld Woman ("Final Flight of Osiris") | Old Woman ("Final Flight of Osiris") |
 Julia FletcherThe Instructor ("The Second Renaissance Part I & II") / Narrator ("World Record") | The Instructor ("The Second Renaissance Part I & II") / Narrator ("World Record") |
| DDane A. Davis01 Versatran Spokesman ("The Second Renaissance Part I & II") | 01 Versatran Spokesman ("The Second Renaissance Part I & II") |
 Debi DerryberryKid ("The Second Renaissance Part I & II") | Kid ("The Second Renaissance Part I & II") |
 Jill TalleyMother ("The Second Renaissance Part I & II") | Mother ("The Second Renaissance Part I & II") |
 Dwight SchultzAdditional Voices ("The Second Renaissance Part I & II") / Monaka ("Matriculated") | Additional Voices ("The Second Renaissance Part I & II") / Monaka ("Matriculated") |
 James Arnold TaylorAdditional Voices ("The Second Renaissance Part I & II") / Ash ("A Detective Story") / Raul ("Matriculated") | Additional Voices ("The Second Renaissance Part I & II") / Ash ("A Detective Story") / Raul ("Matriculated") |
 John DeMitaTeacher ("Kid's Story") | Teacher ("Kid's Story") |
 Hedy BurressCis ("Program") / Yoko ("Beyond") | Cis ("Program") / Yoko ("Beyond") |
 Phil LaMarrDuo ("Program") | Duo ("Program") |
 Victor WilliamsDan ("World Record") | Dan ("World Record") |
 John WesleyDan's Dad ("World Record") | Dan's Dad ("World Record") |
 Alex FernandezTom ("World Record") | Tom ("World Record") |
 Allison SmithReporter ("World Record") | Reporter ("World Record") |
 Matt McKenzieAgent #1 ("World Record") / Agent ("Beyond") / Agent ("A Detective Story") | Agent #1 ("World Record") / Agent ("Beyond") / Agent ("A Detective Story") |
 Tress MacNeilleHousewife ("Beyond") / Kenny ("Beyond") | Housewife ("Beyond") / Kenny ("Beyond") |
 Kath SouciePudgy ("Beyond") / Masa ("Beyond") / Sara ("Beyond") | Pudgy ("Beyond") / Masa ("Beyond") / Sara ("Beyond") |
 Terrence 'T.C.' CarsonClarence ("A Detective Story") | Clarence ("A Detective Story") |
 Rodney SaulsberryChyron ("Matriculated") | Chyron ("Matriculated") |
 Olivia D'AboRox ("Matriculated") | Rox ("Matriculated") |
