Lead singer Oderus Urungus loses his murderous-mojo prompting the rest of the band to embark on an Antarctic quest for the cure.
| Actor | Role |
|---|---|
| DDave BrockieOderus Urungus | Oderus Urungus |
 John DiMaggioBeefcake the Mighty | Beefcake the Mighty |
 'Weird Al' YankovicHimself | Himself |
 Justin RoilandLittle Boy | Little Boy |
| MMyke ChilianDoctor | Doctor |
| MMike DerksThemselves | Themselves |
| GGrant MoningerPunk Rock Dude | Punk Rock Dude |