Four sisters who disagree about everything... except what matters most. Family.
| Actor | Role |
|---|---|
 Cloris LeachmanDolly Amati | Dolly Amati |
 Mercedes RuehlGrace | Grace |
 Dinah ManoffDenise | Denise |
 Sean YoungChristine | Christine |
 Lily KnightDolores | Dolores |
 Lee GrantAunt Spendora | Aunt Spendora |
| EEdith FieldsAunt Loretta | Aunt Loretta |
 Sam McMurrayBrian | Brian |
 Matt WinstonJohnny Barlotta | Johnny Barlotta |
 Gary HershbergerKevin | Kevin |
 Anne DeSalvoCathy | Cathy |
 Sal ViscusoFather Dedice | Father Dedice |
| MMarissa LeighLaura | Laura |
 Robert PicardoGrace's Doctor | Grace's Doctor |
 Mark HarmonLawrence | Lawrence |
 Jamey SheridanPaul | Paul |
 Paul SorvinoJoe | Joe |
 Joe GrecoUncle Frankie | Uncle Frankie |
 Anna BergerStella | Stella |
| DDon MarinoSam | Sam |
| KKivi RogersMike | Mike |
 John CapodiceDanny | Danny |
| FFrederic TuckerStage Manager | Stage Manager |
 Carol Ann SusiTicket Seller | Ticket Seller |
 Niki HarisFlight Attendant | Flight Attendant |
 Maria CinaRockie's Girl | Rockie's Girl |
 Jay AcovoneMr. Moltiani | Mr. Moltiani |
 Michelle JoynerMoviegoer | Moviegoer |
| AAnthony PontrelloNick the Bartender | Nick the Bartender |
| MMichelle ArthurBalletomane | Balletomane |