Amanda Knox served four years in an Italian prison for the murder of her British flatmate Meredith Kercher in Perugia in 2007, always insisting on her innocence. In 2011, she was acquitted on the basis of DNA evidence but prosecutors successfully appealed and her acquittal was struck down. In 2014 she was again found guilty in absentia after a retrial and sentenced to 28 years and six months in jail. The saga came to and end when Italy's highest court overturned the convictions of Ms Knox and her former boyfriend, Italian student Raffaele Sollecito in March 2015. Known burglar Rudy Guede was arrested a short time later following the discovery of his bloodstained fingerprints on Kercher's possessions. He was later found guilty of murder in a fast-track trial and is currently (as of 2019) serving a 16-year prison sentence.
| Actor | Role |
|---|---|
 Amanda KnoxSelf | Self |
| PPatrick LumumbaSelf | Self |
| GGiuliano MigniniSelf | Self |
 Rudy GuedeSelf | Self |
| LLiliana OlivieriNarrator (voice) | Narrator (voice) |
 Tina DaheleyNarrator (voice) | Narrator (voice) |
 Charles MudedeSelf - Seattle Writer | Self - Seattle Writer |
 Manuela ComodiSelf - Prosecutor | Self - Prosecutor |
| GGiancarlo CostagliolaSelf - Prosecutor | Self - Prosecutor |
| FFrancesco MarescaSelf - Kercher Family Lawyer | Self - Kercher Family Lawyer |
| CCurt KnoxSelf - Amanda's Father | Self - Amanda's Father |
| SStephanie KercherSelf - Meredith's Sister | Self - Meredith's Sister |
| LLyle KercherSelf - Meredith's Brother | Self - Meredith's Brother |