 Peter WellerBuckaroo Banzai | Buckaroo Banzai |
 John LithgowLord John Whorfin | Lord John Whorfin |
 Ellen BarkinPenny Priddy | Penny Priddy |
 Jeff GoldblumNew Jersey | New Jersey |
 Christopher LloydJohn Bigboote | John Bigboote |
 Lewis SmithPerfect Tommy | Perfect Tommy |
 Rosalind CashJohn Emdall | John Emdall |
 Robert ItoProfessor Hikita | Professor Hikita |
 Pepe SernaReno Nevada | Reno Nevada |
 Ronald LaceyPresident Widmark | President Widmark |
 Matt ClarkSecretary of Defense | Secretary of Defense |
 Clancy BrownRawhide | Rawhide |
 William TraylorGeneral Catburd | General Catburd |
 Carl LumblyJohn Parker | John Parker |
 Vincent SchiavelliJohn O'Connor | John O'Connor |
 Dan HedayaJohn Gomez | John Gomez |
 Mariclare CostelloSenator Cunningham | Senator Cunningham |
 Bill HendersonCasper Lindley | Casper Lindley |
 Damon HinesScooter Lindley | Scooter Lindley |
 Billy VeraPinky Carruthers | Pinky Carruthers |
 Laura HarringtonMrs. Johnson | Mrs. Johnson |
| MMichael SantoroBilly Travers | Billy Travers |
 Jonathan BanksLizardo Hospital Guard | Lizardo Hospital Guard |
 Robert GrayRadar Blazer | Radar Blazer |
| GGary BisigRadar Blazer | Radar Blazer |
 Kent PerkinsMission Control | Mission Control |
 John AshtonHighway Patrolman | Highway Patrolman |
 Ken MageeDuck Hunter Burt | Duck Hunter Burt |
 James KeaneDuck Hunter Bubba | Duck Hunter Bubba |
 Yakov SmirnoffNational Security Advisor | National Security Advisor |
