A fowl-mouthed turkey and a cast of outrageous puppets embark on a surreal quest to find the lost sequel, ThanksKilling 2.
| Actor | Role |
|---|---|
 Daniel UsajUncle Donny | Uncle Donny |
 Joe HartzlerJefferson | Jefferson |
 Preston AltreeNibla | Nibla |
 Jordan DowneyTurkie / Yomi / WiseTurky / Muff | Turkie / Yomi / WiseTurky / Muff |
 Benjamin SiemonMrs. Turkey | Mrs. Turkey |
 Mike LitzenbergGreg Garbage | Greg Garbage |
 Bridge StuartFrankenTurkey | FrankenTurkey |
 Wanda LustNaked Astronaut | Naked Astronaut |
 Kevin StewartRhonda Worm / PluckMaster / Meowmir | Rhonda Worm / PluckMaster / Meowmir |
| DDavid CroninPie-Lett | Pie-Lett |
| JJeffery A. BakerFlamethrower 1 | Flamethrower 1 |
| RRyan McLellandRimjob Rick | Rimjob Rick |
 Marc MoceriFlowis | Flowis |
 Christina BlevinsNewscaster | Newscaster |
| TTroy SmithBlarth | Blarth |