The biopic charts the life of actor-turned-chief minister J. Jayalalitha and the relationship paving her rapid yet complicated path to power, who served five terms as the Chief Minister for the Indian state of Tamil Nadu.
| Actor | Role |
|---|---|
 Kangana Ranaut'Amma' J. Jayalalithaa | 'Amma' J. Jayalalithaa |
 Arvind SwamyM. J. Ramachandran | M. J. Ramachandran |
 NassarM. Karuna | M. Karuna |
 Bharathi KannanC.N. Annadurai | C.N. Annadurai |
 BhagyashreeSandhya | Sandhya |
 SamuthirakaniR. N. Veerappan | R. N. Veerappan |
 MadhooV. N. Janaki Ramachandran | V. N. Janaki Ramachandran |
 Radha RaviM. R. Radha | M. R. Radha |
 Thambi RamaiahMadhavan | Madhavan |
 PoornaSasi | Sasi |
| AA. R. ManikandanMoorthy | Moorthy |
 Bharath ReddyParty Member | Party Member |
 Vidhya PradeepActress | Actress |
 ShanmugarajanValampuri John | Valampuri John |
| FFlora JacobIndira Gandhi | Indira Gandhi |
| RRajiv Kumar AnejaL K Advani | L K Advani |
 Regena CassandrraSaroja | Saroja |
 Nitya ShettyTrainee doctor | Trainee doctor |