A man's recently transplanted heart leads him on a frantic search to find the donor's killer before a similar fate befalls him.
| Actor | Role |
|---|---|
 Josh LucasTerry | Terry |
 Lena HeadeyElizabeth | Elizabeth |
 Brian CoxVan Doren | Van Doren |
 Bea MillerAngela | Angela |
 Dallas RobertsThe Surgeon | The Surgeon |
 Ulrich ThomsenLethe | Lethe |
 Pablo SchreiberCochius | Cochius |
 Jamie HarroldStanovich | Stanovich |
 Tom Riis FarrellLegethon | Legethon |
 Michael Kenneth WilliamsAcherton | Acherton |
| SScott WintersDr. Averman | Dr. Averman |
 Tom KempDetective Hatzis | Detective Hatzis |
| CCassandre FieringFrances Vieillard | Frances Vieillard |
| KKara LundNurse | Nurse |
| JJohn Timothy BotkaPolice Officer | Police Officer |
 Peg HolzemerElderly Woman In Wheelchair (as Peg Saurman Holzemer) | Elderly Woman In Wheelchair (as Peg Saurman Holzemer) |