When Alzheimer's disease begins to strip away her mother's vibrant personality, a headstrong young woman is forced to return to her oddball family in the conservative small town she recently fled in order to care for her. She quickly realizes she must accept the cruel and warped reality of the disease, and the imperfect beauty of her family, in order to become the daughter they need.
| Actor | Role |
|---|---|
 Julia Louis-DreyfusMidge (voice) | Midge (voice) |
 Abbi JacobsonSarah (voice) | Sarah (voice) |
 Bryan CranstonRob (voice) | Rob (voice) |
 Samira WileyDonimo (voice) | Donimo (voice) |
 Beanie FeldsteinHannah (voice) | Hannah (voice) |
 Seth RogenZach (voice) | Zach (voice) |
 Wanda SykesPaula (voice) | Paula (voice) |
 Bowen YangDale (voice) | Dale (voice) |
 Pamela AdlonDebbie (voice) | Debbie (voice) |
 Sarah SilvermanSukey (voice) | Sukey (voice) |
 Adam ShapiroGregory (voice) | Gregory (voice) |
| FFern GrandinYoung Sarah (voice) | Young Sarah (voice) |
 Phil Rosenthal(voice) | (voice) |
 Pat Finn(voice) | (voice) |
 Sugar Lyn Beard(voice) | (voice) |