Busker Fred and his cat Tabby McTat entertain and delight passersby with music across London. One day, Fred falls, injures his leg, and is whisked away in an ambulance, leaving Tabby alone on the city's streets.
| Actor | Role |
|---|---|
 Jodie WhittakerNarrator (voice) | Narrator (voice) |
 Rob BrydonFred (voice) | Fred (voice) |
 Ṣọpẹ́ DìrísùTabby McTat (voice) | Tabby McTat (voice) |
 Susan WokomaSock (voice) | Sock (voice) |
 Joanna ScanlanPat (voice) | Pat (voice) |
 Cariad LloydPrunella (voice) | Prunella (voice) |
 Felix TandonAmbulance Boy (voice) | Ambulance Boy (voice) |
| RRory FinneganSamuel Sprat (voice) | Samuel Sprat (voice) |
 David HoltAdditional Voices (voice) | Additional Voices (voice) |
| LLizzie WaterworthAdditional Voices (voice) | Additional Voices (voice) |