Jane, an HIV-positive heroin addict, meets Tony, a young AIDS victim with no family, and the two form a bond.
| Actor | Role |
|---|---|
 Samantha MathisJane | Jane |
 Joseph Gordon-LevittTony | Tony |
 Bud CortDr. Geiler | Dr. Geiler |
 Mary WoronovSales Lady | Sales Lady |
 Kimberly ScottDr. Gordon | Dr. Gordon |
 Daniel RoebuckKellygreen | Kellygreen |
 Michelle JohnstonAlice | Alice |
 Nicki MicheauxMartielle | Martielle |
 Derek WebsterDarryl | Darryl |
 William McNamaraStan Bleeker | Stan Bleeker |
| BBarbara PilavinOld Woman Patient | Old Woman Patient |
 Phil FondacaroBob | Bob |
 Gary BullockFigure | Figure |
 Bonnie AaronsWaitress | Waitress |
 Michael AlbalaJohn | John |