Mario and Luigi, plumbers from Brooklyn, find themselves in an alternate universe where evolved dinosaurs live in hi-tech squalor. They're the only hope to save our universe from invasion by the dino dictator, Koopa.
| Actor | Role |
|---|---|
 Bob HoskinsMario Mario | Mario Mario |
 John LeguizamoLuigi Mario | Luigi Mario |
 Dennis HopperKing Koopa | King Koopa |
 Samantha MathisDaisy | Daisy |
 Fisher StevensIggy | Iggy |
 Richard EdsonSpike | Spike |
 Fiona ShawLena | Lena |
 Dana KaminskiDaniella | Daniella |
 Mojo NixonToad | Toad |
 Gianni RussoScapelli | Scapelli |
 Francesca P. RobertsBertha | Bertha |
 Lance HenriksenThe King | The King |
| SSylvia HarmanOld Lady | Old Lady |
 Desiree Marie VelezAngelica | Angelica |
 Andrea PowellBrooklyn Girl | Brooklyn Girl |
| HHeather PendergastBrooklyn Girl | Brooklyn Girl |
| MMelanie SalvatoreBrooklyn Girl | Brooklyn Girl |
| JJohn FiferGoomba Toad | Goomba Toad |
 Don LakeSgt. Simon | Sgt. Simon |
 Terry FinnHatcheck Girl | Hatcheck Girl |
| TThomas MerdisGoomba | Goomba |
 Michael HardingGoomba | Goomba |
| MMichael LynchGoomba | Goomba |
| SScott MactavishGoomba | Goomba |
 Wallace MerckGoomba | Goomba |
| MMona B. FierroNun | Nun |
| KKaren BrigmanNun | Nun |
| CChristi K. WorkNun | Nun |
| JJoy ReeseNun | Nun |
| LLucy AlpaughNun | Nun |