Christopher Reeve portrayed the Man of Steel in four Superman films and played dozens of other roles that displayed his talent and range as an actor, before being injured in a near-fatal horse-riding accident in 1995 that left him paralyzed from the neck down. After becoming a quadriplegic, he became a charismatic leader and activist in the quest to find a cure for spinal cord injuries, as well as a passionate advocate for disability rights and care.
| Actor | Role |
|---|---|
 Christopher ReeveSelf (archive footage) | Self (archive footage) |
 Will ReeveSelf - Christopher's Son | Self - Christopher's Son |
| AAlexandra Reeve GivensSelf - Christopher's Daughter | Self - Christopher's Daughter |
 Gae ExtonSelf | Self |
 Glenn CloseSelf | Self |
 Jeff DanielsSelf | Self |
 Whoopi GoldbergSelf | Self |
| SSteven KirshblumSelf | Self |
 Susan SarandonSelf | Self |
 Pierre SpenglerSelf | Self |
 John KerrySelf | Self |
| BBrooke EllisonSelf | Self |
| MMichael ManganielloSelf | Self |
| LLaurie HawkinsSelf | Self |
| KKevin JohnsonSelf | Self |
| MMatthew ReeveSelf - Christopher's Son | Self - Christopher's Son |
 Richard DonnerSelf (archive footage) | Self (archive footage) |
 Robin WilliamsSelf (archive footage) | Self (archive footage) |
 Jimmy CarterSelf (archive footage) | Self (archive footage) |