Honest and straightforward small-town Shirlee Kenyon chucks her boyfriend and heads for Chicago. Accidentally having to host a radio problem phone-in show, it is clear she is a natural and is hired on the spot. But the station insists she call herself Doctor, and as her popularity grows a local reporter starts digging for the truth. Problem is, the more he is around her the more he fancies her.
| Actor | Role |
|---|---|
 Dolly PartonShirlee Kenyon | Shirlee Kenyon |
 James WoodsJack Russell | Jack Russell |
 Griffin DunneAlan Riegert | Alan Riegert |
 Michael MadsenSteve | Steve |
 Deirdre O'ConnellLily | Lily |
 John SaylesGuy Girardi | Guy Girardi |
 Teri HatcherJanice | Janice |
 Spalding GrayDr. Erdman | Dr. Erdman |
 Jerry OrbachMilo Jacoby | Milo Jacoby |
 Philip BoscoGene Perlman | Gene Perlman |
 Charles FleischerTony | Tony |
 Keith MacKechnieGordon | Gordon |
 Jay ThomasZim Zimmerman | Zim Zimmerman |
 Amy MortonAnn | Ann |
 Paula NewsomeEllen | Ellen |
 Ralph FoodyDesk Clerk | Desk Clerk |
| RRobin EurichBill | Bill |
 Jeff GarlinBob | Bob |
 Paul DinelloCasey | Casey |
 Barnet KellmanTV Director | TV Director |
 Robert KurczPhil | Phil |
 Ray TolerMan at Strip Joint | Man at Strip Joint |
| MMichael OppenheimerMaitre D' | Maitre D' |
| MMichael Jeffrey WoodsPhotographer | Photographer |
 Tom AmandesWaiter | Waiter |
| JJohn GegenhuberWaiter | Waiter |
 James SpinksBartender | Bartender |
| GGreg SobieskiBartender | Bartender |
 Scott BenjaminsonValet | Valet |
| TTom WebbNewscaster | Newscaster |