 Julianne MooreAlice Howland | Alice Howland |
 Kate BosworthAnna Howland-Jones | Anna Howland-Jones |
 Shane McRaeCharlie Howland-Jones | Charlie Howland-Jones |
 Hunter ParrishTom Howland | Tom Howland |
 Alec BaldwinJohn Howland | John Howland |
 Seth GilliamFrederic Johnson | Frederic Johnson |
 Kristen StewartLydia Howland | Lydia Howland |
 Stephen KunkenDr. Benjamin | Dr. Benjamin |
 Erin DarkeJenny | Jenny |
 Daniel GerrollEric Wellman | Eric Wellman |
 Quincy Tyler BernstineNursing Home Administrator | Nursing Home Administrator |
| MMaxine PrescottNursing Home Resident | Nursing Home Resident |
 Orlagh CassidyPrimary Care Doctor | Primary Care Doctor |
 Rosa ArredondoConvention Facilitator | Convention Facilitator |
 Zillah GloryMasha (Three Sisters) | Masha (Three Sisters) |
 Caridad MontanezElena | Elena |
 Cal FreundlichYoung Musician | Young Musician |
| CCharlotte RobsonYoung Musician | Young Musician |
| JJean BurnsOlga (Three Sisters) (uncredited) | Olga (Three Sisters) (uncredited) |
 José BáezHead Waiter (uncredited) | Head Waiter (uncredited) |
 Victoria CartagenaProf. Hooper (uncredited) | Prof. Hooper (uncredited) |
| JJeannette GouldAlzheimer's Patient (uncredited) | Alzheimer's Patient (uncredited) |
 Takako HaywoodAlzheimer's Conference Attendee (uncredited) | Alzheimer's Conference Attendee (uncredited) |
| SSamantha KellyTV Reporter (uncredited) | TV Reporter (uncredited) |
| DDiane KimbrellAlzheimer's Patient (uncredited) | Alzheimer's Patient (uncredited) |
| CCat LynchPinkberry Worker (uncredited) | Pinkberry Worker (uncredited) |
 Joanne PericaCrying Woman (uncredited) | Crying Woman (uncredited) |
| JJamie Lee PetronisPinkberry Worker (uncredited) | Pinkberry Worker (uncredited) |
 Nancy Ellen ShoreNurse (uncredited) | Nurse (uncredited) |
 Eha UrbsaluAlice's Mother (uncredited) | Alice's Mother (uncredited) |
