The rags-to-riches tale of country western queen, Tammy Wynette, from her impoverished childhood to country's First Lady and her two rocky marriages to fellow superstar George Jones, who had been her childhood idol.
| Actor | Role |
|---|---|
 Annette O'TooleTammy Wynette | Tammy Wynette |
 Tim McIntireGeorge Jones | George Jones |
 Cooper HuckabeeEuple Byrd | Euple Byrd |
 James HamptonBilly Sherrill | Billy Sherrill |
| HHelen Page CampMother Pugh | Mother Pugh |
| JJohn Van HorneCharlie Carter | Charlie Carter |
 Monica ParkerJane | Jane |
 Ivy BethuneClara Jones | Clara Jones |
 Rudy BondGrandfather | Grandfather |
| DDorothy ButtsDoris | Doris |
| RRobert CarnegieGlen Daley | Glen Daley |
| RRhodie CoganGrandmother | Grandmother |
| FFredric CookRichard | Richard |
| BBuddy FarmerM.C. | M.C. |
| JJennifer GayGirl | Girl |
 Bert HinchmanDr. Barnes | Dr. Barnes |
| RRosanna HuffmanMrs. Hadley | Mrs. Hadley |
 Mickey JonesEddie | Eddie |
| DDan MagieraSlim | Slim |
| BBob McClurgDr. Egly | Dr. Egly |
| LLori McGinleyReceptionist | Receptionist |
| JJohn MediciEngineer | Engineer |
| PPaul NapierDr. Harris | Dr. Harris |
| DDouglas RobinsonUncle Karl | Uncle Karl |
 Ken SansomDr. Pegram | Dr. Pegram |
| KKelly SarberEuple's Sister | Euple's Sister |
| CChris ShafferHotel Manager | Hotel Manager |
| MMorgan StoddardBandleader | Bandleader |
 Bunny SummersMrs. Watkins | Mrs. Watkins |
 Gwen Van DamMrs. Sims | Mrs. Sims |