When seven aliens crash land in the desert night, Stan Lee discovers that they are being chased by a top-secret military force led by Mr. Cross and his Chinese technical assistant, Lily. Stan hides the distressed aliens in his Malibu beach house, but when the evil reptilian Taegons invade Planet Earth days later, Stan needs to act quick! He teaches the seven aliens how to become superheroes, and in a climactic battle, Stan and the Mighty 7 defeat the Taegon invaders.
| Actor | Role |
|---|---|
 Jim BelushiMr. Cross (voice) | Mr. Cross (voice) |
 Armie HammerStrong Arm (voice) | Strong Arm (voice) |
 Christian SlaterLazer Lord (voice) | Lazer Lord (voice) |
 Mayim BialikLady Lightning (voice) | Lady Lightning (voice) |
 Teri HatcherSilver Skylark (voice) | Silver Skylark (voice) |
 Stan LeeStan Lee (voice) | Stan Lee (voice) |
 FleaRoller Man (voice) | Roller Man (voice) |
 Darren CrissMicro (voice) | Micro (voice) |
 Sean AstinKid Kinergy (voice) | Kid Kinergy (voice) |
 Michael IronsideXanar (voice) | Xanar (voice) |
 Frank WelkerGeneral (voice) | General (voice) |
 John DiMaggioNot listed | Not listed |
 Kevin Michael RichardsonNot listed | Not listed |
 Alanna UbachNot listed | Not listed |