On its maiden flight, the crew of America's first supersonic transport learns that it may not be able to land, due to an act of sabotage and a deadly flu onboard.
| Actor | Role |
|---|---|
 Barbara AndersonCarla Stanley | Carla Stanley |
 Bert ConvyTim Vernon | Tim Vernon |
 Peter GravesPaul Whitley | Paul Whitley |
 Lorne GreeneMarshall Cole | Marshall Cole |
 Season HubleyAnne Redding | Anne Redding |
 Tina LouiseMae | Mae |
 George MaharisLes Phillips | Les Phillips |
 Burgess MeredithWilly Basset | Willy Basset |
 Doug McClureHank Fairbanks | Hank Fairbanks |
 Martin MilnerLyle Kingman | Lyle Kingman |
 Brock PetersDr. Ralph Therman | Dr. Ralph Therman |
 Robert ReedCaptain Jim Walsh | Captain Jim Walsh |
 Susan StrasbergNancy Kingman | Nancy Kingman |
 Misty RoweAngela Garland | Angela Garland |
 Billy CrystalDavid | David |
 John de LancieBob Connors | Bob Connors |
 Regis PhilbinHarry Carter | Harry Carter |
 Robert ItoFlight Engineer Roy Nakamura | Flight Engineer Roy Nakamura |
| TTom StewartEric Brent | Eric Brent |
 Sherwood PriceMickey | Mickey |
| PPaul NapierEddy | Eddy |
| TTim PeltLinus | Linus |
| AAlain PatrickController Girard | Controller Girard |
 Richard DerrGovernor Stensky | Governor Stensky |
 Ric CarrottReporter | Reporter |
| SShawn RandallPassenger | Passenger |
| WWalter MaslowPassenger | Passenger |