 Henry FondaClay Spencer | Clay Spencer |
 Maureen O'HaraOlivia Spencer | Olivia Spencer |
 James MacArthurClayboy Spencer | Clayboy Spencer |
 Donald CrispGrandpa Spencer | Grandpa Spencer |
 Wally CoxPreacher Goodman | Preacher Goodman |
 Mimsy FarmerClaris Coleman | Claris Coleman |
 Virginia GreggMiss Parker | Miss Parker |
 Lillian BronsonGrandma Spencer | Grandma Spencer |
 Whit BissellDr. Campbell | Dr. Campbell |
 Hayden RorkeColonel Coleman | Colonel Coleman |
| KKathy BennettMinnie-Cora Cook | Minnie-Cora Cook |
 Dub TaylorPercy Cook | Percy Cook |
 Hope SummersMother Ida | Mother Ida |
 Ken MayerMr. John | Mr. John |
 Rusty LaneUniversity Dean (uncredited) | University Dean (uncredited) |
 Barbara McNairGraduation Singer (uncredited) | Graduation Singer (uncredited) |
 Kym KarathPattie-Cake Spencer (uncredited) | Pattie-Cake Spencer (uncredited) |
 Victor FrenchSpencer Brother (uncredited) | Spencer Brother (uncredited) |
 Med FlorySpencer Brother (uncredited) | Spencer Brother (uncredited) |
 Michael GreeneSpencer Brother (uncredited) | Spencer Brother (uncredited) |
 Mike HenrySpencer Brother (uncredited) | Spencer Brother (uncredited) |
| LLarry D. MannSpencer Brother (uncredited) | Spencer Brother (uncredited) |
 James O'HaraSpencer Brother (uncredited) | Spencer Brother (uncredited) |
| RRay SavageSpencer Brother (uncredited) | Spencer Brother (uncredited) |
 Bronwyn FitzSimonsDean's Secretary (uncredited) | Dean's Secretary (uncredited) |
 Veronica CartwrightBecky Spencer (uncredited) | Becky Spencer (uncredited) |
| WWilliam BreenMountain Boy (uncredited) | Mountain Boy (uncredited) |
| MMichele DavesDonnie Spencer (uncredited) | Donnie Spencer (uncredited) |
| MMartin EricOdell Harper (uncredited) | Odell Harper (uncredited) |
 Robert "Buzz" HenryAmbulance Driver (uncredited) | Ambulance Driver (uncredited) |
