 Michael Jai WhiteAl Simmons / Spawn | Al Simmons / Spawn |
 Martin SheenJason Wynn | Jason Wynn |
 John LeguizamoClown / Violator | Clown / Violator |
 Theresa RandleWanda Blake | Wanda Blake |
 Nicol WilliamsonCogliostro | Cogliostro |
 D. B. SweeneyTerry Fitzgerald | Terry Fitzgerald |
 Melinda ClarkeJessica Priest | Jessica Priest |
 Miko HughesZack | Zack |
 Sydni BeaudoinCyan | Cyan |
 Michael PapajohnGlen, Zack's Dad | Glen, Zack's Dad |
 Frank WelkerThe Devil Malebolgia (voice) | The Devil Malebolgia (voice) |
| TTony HaneyAfrican Liaison | African Liaison |
 Todd McFarlaneBum | Bum |
 Simon RheeHong Kong Military Air Base Person (uncredited) | Hong Kong Military Air Base Person (uncredited) |
| RRobia LaMorteXNN Reporter | XNN Reporter |
 John CothranAfrican Liaison | African Liaison |
| CCaroline GibsonNews Anchor | News Anchor |
| MMarc RobinsonPunk #1 | Punk #1 |
 Chris CoppolaPunk #2 | Punk #2 |
 Jay CaputoPunk #3 | Punk #3 |
| DDarryl WarrenSecurity Guard | Security Guard |
 Mike AkrawiForeign Dignitary #1 | Foreign Dignitary #1 |
| RRomeo AkrawiForeign Dignitary #2 | Foreign Dignitary #2 |
 Jack ColemanDoctor | Doctor |
 Laura IntervalAngela (as Laura Stepp) | Angela (as Laura Stepp) |
| GGarrison M. SingerAnesthesiologist | Anesthesiologist |
 John KoyamaHong Kong Military Air Base Security (uncredited) | Hong Kong Military Air Base Security (uncredited) |
| AAl GotoHong Kong Military Air Base Person (uncredited) | Hong Kong Military Air Base Person (uncredited) |
 Roger YuanKorean Soldier (uncredited) | Korean Soldier (uncredited) |
| AAngelie AlmendareDiplomat's Wife (uncredited) | Diplomat's Wife (uncredited) |
