Comet longs to be taken seriously as a full-fledged space chimp. He journeys to the fantastical Planet Malgor and bonds with the adorable alien Kilowatt, living out his ultimate fantasy. However, it's time for Comet to prove himself when the feared alien ruler Zartog takes over Mission Control! Comet must show he has the right stuff, and join fellow chimps Ham, Luna and Titan, to save the day.
| Actor | Role |
|---|---|
 Tom KennyHam / Reporter #1 (voice) | Ham / Reporter #1 (voice) |
 Zack ShadaComet (voice) | Comet (voice) |
 Patrick WarburtonTitan (voice) | Titan (voice) |
 Cheryl HinesLuna (voice) | Luna (voice) |
 Carlos AlazraquiHouston / Piddles The Clown / Camera Guy (voice) | Houston / Piddles The Clown / Camera Guy (voice) |
 Laura BaileyKilowatt / Computer Voice (voice) | Kilowatt / Computer Voice (voice) |
 John DiMaggioZartog / Human #1 / Human #2 (voice) | Zartog / Human #1 / Human #2 (voice) |
 Stanley TucciSenator (voice) | Senator (voice) |
 Patrick BreenDr. Bob (voice) | Dr. Bob (voice) |
 Jane LynchDr. Poole (voice) | Dr. Poole (voice) |
 Omid AbtahiDr. Jagu / Reporter #2 (voice) | Dr. Jagu / Reporter #2 (voice) |
 Noreen ReardonAlien #1 (voice) | Alien #1 (voice) |
 David MichieAlien #2 (voice) | Alien #2 (voice) |