 Andy SambergHam III (voice) | Ham III (voice) |
 Cheryl HinesLuna (voice) | Luna (voice) |
 Jeff DanielsZartog (voice) | Zartog (voice) |
 Patrick WarburtonTitan (voice) | Titan (voice) |
 Kristin ChenowethKilowatt (voice) | Kilowatt (voice) |
 Kenan ThompsonRingmaster (voice) | Ringmaster (voice) |
 Zack ShadaComet / Nava Boy (voice) | Comet / Nava Boy (voice) |
 Carlos AlazraquiHouston (voice) | Houston (voice) |
 Omid AbtahiDr. Jagu (voice) | Dr. Jagu (voice) |
 Patrick BreenDr. Bob (voice) | Dr. Bob (voice) |
 Jane LynchDr. Poole (voice) | Dr. Poole (voice) |
 Kath SoucieDr. Smothers (voice) | Dr. Smothers (voice) |
 Stanley TucciSenator (voice) | Senator (voice) |
 Wally WingertSplork / Infinity Probe / Pappy Ham (voice) | Splork / Infinity Probe / Pappy Ham (voice) |
 Jessica Gee-GeorgeShip Voice / Infinity Probe / Additional Voices (voice) | Ship Voice / Infinity Probe / Additional Voices (voice) |
 Tom KennyNewsreel (voice) | Newsreel (voice) |
 Jason HarrisGuard (voice) | Guard (voice) |
 Jess HarnellAdditional Voices (voice) | Additional Voices (voice) |
 Ellie HarvieAdditional Voices (voice) | Additional Voices (voice) |
 Caitlin McKennaAdditional Voices (voice) | Additional Voices (voice) |
