B-Dawg, Mudbud, Budderball, and all the rest of the Buddies are back, but this time, they're setting their sights even higher -- as in, the moon! With the help of their new pals Spudnick and Gravity, these pooches are go for launch. But to pull off their moon landing and make it home safely, our canine heroes will have to summon all their bravery and imagination...
| Actor | Role |
|---|---|
 Josh FlitterBudderball (voice) | Budderball (voice) |
 Skyler GisondoB-Dawg (voice) | B-Dawg (voice) |
| FField CateBuddha (voice) | Buddha (voice) |
 Liliana MumyRosebud (voice) | Rosebud (voice) |
 Henry HodgesMudbud (voice) | Mudbud (voice) |
 Diedrich BaderYuri | Yuri |
 Jason EarlesSpudnick (voice) | Spudnick (voice) |
 Amy SedarisGravity (voice) | Gravity (voice) |
 Pat FinnBill Wolfson | Bill Wolfson |
 Kevin WeismanDr. Finkel | Dr. Finkel |
 Nolan GouldSam | Sam |
 Quinn LordPete | Pete |
 Gig MortonBilly | Billy |
 Nico GhisiBartleby | Bartleby |
 Sophia LudwigAlice | Alice |
 Lochlyn MunroSlats Bentley | Slats Bentley |
 Kendall CrossSam's Mom | Sam's Mom |
 Mike DopudInvestor #1 | Investor #1 |
 Bill FagerbakkePi | Pi |
 Chris GauthierTad's Cameraman | Tad's Cameraman |
 C. Ernst HarthGuard | Guard |
 Michael TeigenDeputy Dan | Deputy Dan |
 Ali HillisAstro Spalding | Astro Spalding |
 Wayne WildersonTad Thompson | Tad Thompson |
| TTaku KawaiCarl | Carl |
| CCarolyn SadowskaThe Queen | The Queen |
 Jadyn WongChinese Reporter | Chinese Reporter |