A dramatization of the relationship between heart surgery pioneers Alfred Blalock and Vivien Thomas.
| Actor | Role |
|---|---|
 Alan RickmanDr. Alfred Blalock | Dr. Alfred Blalock |
 Yasiin BeyVivien Thomas | Vivien Thomas |
 Kyra SedgwickMary Blalock | Mary Blalock |
 Gabrielle UnionClara Thomas | Clara Thomas |
 Merritt WeverMrs. Saxon | Mrs. Saxon |
 Charles S. DuttonWilliam Thomas | William Thomas |
 Mary Stuart MastersonDr. Helen Taussig | Dr. Helen Taussig |
 Irene ZieglerFrancis Grebel | Francis Grebel |
 Luray CooperCharles Manlove | Charles Manlove |
| CCliff McMullenLodel Williams | Lodel Williams |
| CClayton LeBouefHarold Thomas | Harold Thomas |
 James LewisMedical Intern | Medical Intern |