Ten-year-old Nikki is a precocious child suffering from Rett Syndrome. Unwilling to help her the doctors, instead, want to write her off as a mentally handicapped person.
| Actor | Role |
|---|---|
| KKyley StathamNikki Best | Nikki Best |
 Jessica SteenTerry Best | Terry Best |
 Sarah GadonNikki Best (voice) | Nikki Best (voice) |
 Hugh ThompsonSean Best | Sean Best |
 Margot KidderJoan | Joan |
 Melanie Nicholls-KingMonique | Monique |
| KKelsey KoenigRebecca Best | Rebecca Best |
| AAndrew GrantRicky Best | Ricky Best |
 Michael LyonsThomas Best | Thomas Best |
| JJerret LemayJake Best | Jake Best |
| DDesmond LanganJimmie Best | Jimmie Best |
 Kristine WilsonLuanne Best | Luanne Best |
 Jay BrazeauDr. Stone | Dr. Stone |
| MMichael LawrenchukLuke | Luke |
 Tom AnnikoPrincipal | Principal |
 Sharon BajerTeacher | Teacher |