 RihannaSmurfette (voice) | Smurfette (voice) |
 James CordenNo Name (voice) | No Name (voice) |
 Nick OffermanKen (voice) | Ken (voice) |
 JP KarliakGargamel / Razamel (voice) | Gargamel / Razamel (voice) |
 Dan LevyJoel (voice) | Joel (voice) |
 Amy SedarisJaunty (voice) | Jaunty (voice) |
 Natasha LyonneMama Poot (voice) | Mama Poot (voice) |
 Sandra OhMoxie Smurf (voice) | Moxie Smurf (voice) |
 Jimmy KimmelTardigrade (voice) | Tardigrade (voice) |
 Octavia SpencerAsmodius (voice) | Asmodius (voice) |
 Nick KrollChernobog (voice) | Chernobog (voice) |
 Hannah WaddinghamJezebeth (voice) | Jezebeth (voice) |
 Alex WinterHefty Smurf (voice) | Hefty Smurf (voice) |
 Maya ErskineVanity Smurf (voice) | Vanity Smurf (voice) |
 Billie LourdWorry Smurf (voice) | Worry Smurf (voice) |
 Xolo MaridueñaBrainy Smurf (voice) | Brainy Smurf (voice) |
 Kurt RussellRon (voice) | Ron (voice) |
 John GoodmanPapa Smurf (voice) | Papa Smurf (voice) |
 Chris MillerGrouchy Smurf / Camouflage Smurf (voice) | Grouchy Smurf / Camouflage Smurf (voice) |
 Rachel ButeraAzrael / List Maker Smurf (voice) | Azrael / List Maker Smurf (voice) |
 Conrad VernonButler (voice) | Butler (voice) |
| TTyler PetersonBellhop (voice) | Bellhop (voice) |
| MMarshmelloTurtle (voice) | Turtle (voice) |
 Chris PrynoskiQuiet Smurf / Way Back There Smurf / Shark Taming Smurf (voice) | Quiet Smurf / Way Back There Smurf / Shark Taming Smurf (voice) |
 Spencer XSound Effects Smurf (voice) | Sound Effects Smurf (voice) |
| HHugo MillerClumsy Smurf (voice) | Clumsy Smurf (voice) |
| RRyan NaylorCalendar Smurf (voice) | Calendar Smurf (voice) |
 Jonny ManganelloBaker Smurf (voice) | Baker Smurf (voice) |
 DJ SnakeDJ Snake (voice) | DJ Snake (voice) |
 Léa EluiFeatured Paris Disco Dancer (voice) | Featured Paris Disco Dancer (voice) |
