Smosh Hospital is a live streamed parody of a classic hospital drama, where the cast is continually surprised by last minute line changes, prop mishaps and improvised bits designed to make everyone break character. If they break or make a mistake, they get replaced by their double - creating a rotating cast of characters and annihilating the show!
| Actor | Role |
|---|---|
 Amanda Lehan-CantoCowboy. | Cowboy. |
 Angela GiarratanaDr. Condo | Dr. Condo |
 Anthony PadillaNurse/Waldo | Nurse/Waldo |
 ArashaDr. Boone | Dr. Boone |
 Chanse McCraryOrange Pinata Patient/The Chosen | Orange Pinata Patient/The Chosen |
 Courtney MillerNurse O'Connell | Nurse O'Connell |
 Damien C. HaasMr.Finbuck/Pipe Patient/Grim Reaper | Mr.Finbuck/Pipe Patient/Grim Reaper |
 Ian HecoxDr. Edward Condo | Dr. Edward Condo |
 Keith Leak Jr.Arm Patient 1 | Arm Patient 1 |
 Noah GrossmanArm Patient 2 | Arm Patient 2 |
 Olivia SuiDr. Green | Dr. Green |
 Shayne ToppNurse O'Connell | Nurse O'Connell |
 Spencer AgnewThe Chosen/Fred Darts | The Chosen/Fred Darts |
 Tommy BoweDr. Boone | Dr. Boone |
 Trevor EvartsDr. Green | Dr. Green |