Set in the early 1960's, Artie, the deranged janitor from Slaughtered Secretaries, returns to wreak havoc on a doctor and her patients. Dr. Sorens (Dawn Murphy) has taken Artie under her wing and given him a job, not believing that he killed the three secretaries five years earlier. But she's wrong and they all pay the price for her ignorance!
| Actor | Role |
|---|---|
 Dawn MurphyDr. Sorens | Dr. Sorens |
| SSal LongoArtie (as Ben Morgan) | Artie (as Ben Morgan) |
 Tina KrauseMs. Winters | Ms. Winters |
 Debbie DNurse | Nurse |
 Deana EnochesSocialite | Socialite |
| CClancey McCauley(archival footage) | (archival footage) |
| CCarol Livingston(archival footage) | (archival footage) |
 Gary WhitsonVoice (uncredited) | Voice (uncredited) |