 Matthew McConaugheyBuster Moon (voice) | Buster Moon (voice) |
 Reese WitherspoonRosita (voice) | Rosita (voice) |
 Seth MacFarlaneMike (voice) | Mike (voice) |
 Scarlett JohanssonAsh (voice) | Ash (voice) |
 John C. ReillyEddie (voice) | Eddie (voice) |
 Taron EgertonJohnny (voice) | Johnny (voice) |
 Tori KellyMeena (voice) | Meena (voice) |
 Jennifer SaundersNana (voice) | Nana (voice) |
 Jennifer HudsonYoung Nana (voice) | Young Nana (voice) |
 Garth JenningsMiss Crawly / Additional Voices (voice) | Miss Crawly / Additional Voices (voice) |
 Peter SerafinowiczBig Daddy (voice) | Big Daddy (voice) |
 Nick KrollGunter (voice) | Gunter (voice) |
 Beck BennettLance (voice) | Lance (voice) |
 Jay PharoahMeena's Grandfather (voice) | Meena's Grandfather (voice) |
 Nick OffermanNorman (voice) | Norman (voice) |
 Leslie JonesMeena's Mother (voice) | Meena's Mother (voice) |
 Rhea PerlmanJudith (voice) | Judith (voice) |
 Laraine NewmanMeena's Grandmother / Additional Voices (voice) | Meena's Grandmother / Additional Voices (voice) |
 Adam BuxtonStan (voice) | Stan (voice) |
 Brad MorrisBaboon (voice) | Baboon (voice) |
 Bill FarmerNews Reporter Dog (voice) | News Reporter Dog (voice) |
| OOscar JenningsPiglet (voice) | Piglet (voice) |
| LLeo JenningsPiglet (voice) | Piglet (voice) |
| CCaspar JenningsPiglet (voice) | Piglet (voice) |
| AAsa JenningsPiglet (voice) | Piglet (voice) |
 Carlos AlazraquiAdditional Voices (voice) | Additional Voices (voice) |
 Wes AndersonDaniel (voice) | Daniel (voice) |
 Sara MannAdditional Voices (voice) | Additional Voices (voice) |
| IIgor KhaitAdditional Voices (voice) | Additional Voices (voice) |
 David ArnottAdditional Voices (voice) | Additional Voices (voice) |
