In post-9/11 New York City, an eclectic group of citizens find their lives entangled, personally, romantically, and sexually, at Shortbus, an underground Brooklyn salon infamous for its blend of art, music, politics, and carnality.
| Actor | Role |
|---|---|
 Sook-Yin LeeSofia | Sofia |
 Paul DawsonJames | James |
 PJ DeBoyJamie | Jamie |
 Lindsay BeamishSeverin | Severin |
 Jay BrannanCeth | Ceth |
 Raphael BarkerRob | Rob |
 Adam HardmanJesse | Jesse |
 Peter SticklesCaleb | Caleb |
| AAlan MandellTobias, the Mayor | Tobias, the Mayor |
 Stephen Kent JusickCreamy | Creamy |
 David PittuJacuzzi Hunter | Jacuzzi Hunter |
| JJeff WhittyJacuzzi Hunted | Jacuzzi Hunted |
 Mickey CottrellDead Man in the Jacuzzi | Dead Man in the Jacuzzi |
 Mary Beth PeilAnn, Our Lady of the Gutter | Ann, Our Lady of the Gutter |
 Shanti CarsonLeah | Leah |
| JJan HilmerNick | Nick |
 Justin Vivian BondMx Justin Vivian Bond | Mx Justin Vivian Bond |
| BBradford ScobieDr. Donut | Dr. Donut |
 Murray HillMurray Hill | Murray Hill |
| EEthan Eunson-ConnSex-Not-Bombs Room D.J. | Sex-Not-Bombs Room D.J. |
 Jonathan CaouetteBlondie-Grabber | Blondie-Grabber |
| DDerek JacksonDerek | Derek |
| RRachel FriedmanYenta Voice (voice) | Yenta Voice (voice) |
 Paul Oakley StovallMagnus | Magnus |
| RReg VermueAlbino | Albino |
| RRay RivasShabbos Goy | Shabbos Goy |
| BBitchBitch | Bitch |
| LLex VaughnBucky | Bucky |
 Rachael C. SmithZoey | Zoey |
 Yolonda RossFaustus | Faustus |