Shoot the Messenger follows one man's painful journey towards self-discovery. On the way he finds both his own attitudes and the expectations of his community challenged.
| Actor | Role |
|---|---|
 David OyelowoJoseph Pascale | Joseph Pascale |
 Nikki Amuka-BirdHeather | Heather |
 Ariyon BakareElroy | Elroy |
| JJay ByrdMabel | Mabel |
 Sharon Duncan-BrewsterSherlene | Sherlene |
 Daniel KaluuyaReece | Reece |
 David GyasiTimothy | Timothy |
 Junior LaniyanPatrick | Patrick |
 Chiké OkonkwoKwame | Kwame |
 Eric Kofi AbrefaYannek | Yannek |
 Anjela Lauren SmithMaureen | Maureen |
 Richard PeppleRoy | Roy |
 Charles MneneGermal | Germal |
| MMedina AijikawoSarah | Sarah |
 Sian Ejiwunmi-Le BerreJanine | Janine |
 Clare PerkinsMary Gibbs | Mary Gibbs |
 Heather BleasdaleTracey Willis | Tracey Willis |
 Clive RoweRev. Wilson | Rev. Wilson |
 Brian BovellCouncillor Watts | Councillor Watts |
 Richard BlackwoodSir Galahad - Radio DJ | Sir Galahad - Radio DJ |
 Oscar JamesRodney Pascale | Rodney Pascale |
| JJoan HooleyIvaline Pascale | Ivaline Pascale |
| EEamon GeogheganBob | Bob |
 Troy GlasgowWarren | Warren |
| KKyle Joseph-PetersSherman | Sherman |
| HHilja Lindsay ParkinsonL'Braia | L'Braia |
| JJasmine Pride-GarrettMalika | Malika |
| GGraham BoheaFred | Fred |
 Tanya RonderMrs Morton | Mrs Morton |
| BBen PittsMr Watson | Mr Watson |