Suicidal poet Archy tries to end his life by jumping off a bridge, but awakens to find he has assumed the life of a cockroach and has become a part of a community of creatures living in a newspaper office. He also discovers that he can still write poetry, using a typewriter, and begins to enjoy his new life. Archy develops deep feelings for the lovely but self-destructive cat Mehitabel, but will have to fight to win her from bad-boy tomcat Bill.
| Actor | Role |
|---|---|
 Carol ChanningMehitabel (voice) | Mehitabel (voice) |
 Eddie BrackenArchy (voice) | Archy (voice) |
 Alan ReedBig Bill (voice) | Big Bill (voice) |
 John CarradineTyrone T. Tattersall (voice) | Tyrone T. Tattersall (voice) |
 Hal SmithFreddie the Rat / Prissy Cat (voice) | Freddie the Rat / Prissy Cat (voice) |
 Joan GerberPenelope the Fat Cat / Ladybugs of the Evening (voice) | Penelope the Fat Cat / Ladybugs of the Evening (voice) |
| SSal DelanoBeatnik Spider (voice) | Beatnik Spider (voice) |
 Ken SansomRosie the Cat (voice) | Rosie the Cat (voice) |
 Byron KaneNewspaperman (voice) | Newspaperman (voice) |