 Basil RathboneSherlock Holmes | Sherlock Holmes |
 Nigel BruceDoctor Watson | Doctor Watson |
 Lionel AtwillProfessor Moriarty | Professor Moriarty |
 William Post Jr.Dr. Franz Tobel | Dr. Franz Tobel |
 Kaaren VerneCharlotte Eberli | Charlotte Eberli |
 Dennis HoeyInspector Lestrade | Inspector Lestrade |
 Holmes HerbertSir Reginald | Sir Reginald |
 Mary GordonMrs. Hudson | Mrs. Hudson |
 Harry CordingJack Brady (uncredited) | Jack Brady (uncredited) |
| HHarold De BeckerPeg Leg (uncredited) | Peg Leg (uncredited) |
 Paul FixMueller (uncredited) | Mueller (uncredited) |
 Henry VictorProfessor Frederic Hoffner (uncredited) | Professor Frederic Hoffner (uncredited) |
| JJohn BurtonRAF Officer (uncredited) | RAF Officer (uncredited) |
 Paul BryarSwiss Waiter (uncredited) | Swiss Waiter (uncredited) |
 Whit BissellLondon Bobbie (uncredited) | London Bobbie (uncredited) |
 Rudolph AndersBraun (uncredited) | Braun (uncredited) |
 Colin KennyScotland Yard Detective (uncredited) | Scotland Yard Detective (uncredited) |
| GGeorge Burr MacannanGottfried (uncredited) | Gottfried (uncredited) |
 Harry WoodsKurt (uncredited) | Kurt (uncredited) |
