Sherlock Holmes and Dr. Watson embark on a search for Cleopatra's ancient necklace, which has been stolen.
| Actor | Role |
|---|---|
 Christopher LeeSherlock Holmes | Sherlock Holmes |
 Thorley WaltersDr. Watson | Dr. Watson |
 Hans SöhnkerMoriarty | Moriarty |
 Hans NielsenCooper | Cooper |
 Senta BergerEllen | Ellen |
 Ivan DesnyPaul | Paul |
 Wolfgang LukschyPeter | Peter |
 Leon AskinCharles | Charles |
 Edith Schultze-WestrumMrs. Hudson | Mrs. Hudson |
 Bruno W. PantelAuctioneer | Auctioneer |
| HHeinrich GiesBuyer | Buyer |
 Bernard LajarrigeFrench | French |
 Linda SiniProstitute | Prostitute |
 Roland ArmontelPhysician | Physician |
| MMax StrassbergJohnny | Johnny |
| DDanièle ArgenceLibrarian | Librarian |
 Franco GiacobiniCollector | Collector |
| WWaldemar FrahmButler | Butler |
| RRena HortenEmily | Emily |