 Johnny DeppSherlock Gnomes (voice) | Sherlock Gnomes (voice) |
 Emily BluntJuliet (voice) | Juliet (voice) |
 James McAvoyGnomeo (voice) | Gnomeo (voice) |
 Chiwetel EjioforDr. Watson (Voice) | Dr. Watson (Voice) |
 Mary J. BligeIrene (voice) | Irene (voice) |
 Stephen MerchantParis (voice) | Paris (voice) |
 Michael CaineLord Redbrick (voice) | Lord Redbrick (voice) |
 Dexter FletcherGargoyle Reggie (voice) | Gargoyle Reggie (voice) |
 James HongSalt Shaker (voice) | Salt Shaker (voice) |
 Ashley JensenNanette (voice) | Nanette (voice) |
 Matt LucasBenny (voice) | Benny (voice) |
 Ozzy OsbourneFawn (voice) | Fawn (voice) |
 Maggie SmithLady Bluebury (voice) | Lady Bluebury (voice) |
 Julie WaltersMrs. Montague (voice) | Mrs. Montague (voice) |
 Jamie DemetriouMoriarty (voice) | Moriarty (voice) |
 Richard WilsonMr. Capulet (voice) | Mr. Capulet (voice) |
 Kelly AsburyGoons (voice) | Goons (voice) |
| GGang ChiVideo Game Player (voice) | Video Game Player (voice) |
| JJulio BonetMankini (voice) | Mankini (voice) |
 Rosalie CraigNimrod Captain (voice) | Nimrod Captain (voice) |
| EEve WebsterMrs. Udderson / Big Eared Gnome (voice) | Mrs. Udderson / Big Eared Gnome (voice) |
| GGary BradburyBarry (voice) | Barry (voice) |
| SSteve Hamilton ShawSteve Gnome (voice) | Steve Gnome (voice) |
| LLeyla HobartPolicewoman (voice) | Policewoman (voice) |
 Javone PrinceGargoyle Ronnie (voice) | Gargoyle Ronnie (voice) |
 Dan StarkeyGregson / News Reporter (voice) | Gregson / News Reporter (voice) |
 John StevensonBig Boy Gorilla (voice) | Big Boy Gorilla (voice) |
 Stephen WightBridge Operator (voice) | Bridge Operator (voice) |
| XXin ZhaoStackable Heads (voice) | Stackable Heads (voice) |
