Early in his crime-solving career, Sherlock Holmes attempts to prevent Moriarty from cornering the heroin market.
| Actor | Role |
|---|---|
 James D'ArcySherlock Holmes | Sherlock Holmes |
 Roger MorlidgeDr. Watson | Dr. Watson |
 Vincent D'OnofrioMoriarty | Moriarty |
 Gabrielle AnwarRebecca Doyle | Rebecca Doyle |
 Richard E. GrantMycroft | Mycroft |
 Nicholas GecksInspector Lestrade | Inspector Lestrade |
 Struan RodgerBen Harrington | Ben Harrington |
 Peter-Hugo DalyHenry Coot | Henry Coot |
 Mihai BisericanuSgt. Cox | Sgt. Cox |
 Sandu Mihai GruiaDr. Cruickshank | Dr. Cruickshank |
| CConstantin BărbulescuCaptor #1 | Captor #1 |
| DDoru DumitrescuCaptor #2 | Captor #2 |
| NNatalie EsterPretty Young Hopeful | Pretty Young Hopeful |
 Ioana AburVictoria | Victoria |
| FFritha GoodeyAnna | Anna |
 Valentin PopescuKiller | Killer |
 Anca AndroneNurse | Nurse |