Sharmajee Ki Beti intricately weaves the lives of Jyoti, Kiran, and Tanvi, all with the common surname of Sharma as they navigate urban loneliness, societal pressures, and gender expectations. Amidst their struggles, teenagers, Swati and Gurveen journey through puberty and maternal neglect, adding depth to this humorous and heart-warming tale of resilience, aspirations, and coming-of-age.
| Actor | Role |
|---|---|
 Saiyami KherTanvi Sharma | Tanvi Sharma |
 Sakshi TanwarJyoti Sharma | Jyoti Sharma |
 Divya DuttaKiran Sharma | Kiran Sharma |
 Sharib HashmiSudhir Sharma | Sudhir Sharma |
 Parvin DabasVinod Sharma | Vinod Sharma |
 Arista MehtaGurveen Sharma | Gurveen Sharma |
| VVanshika TapariaSwati Sharma | Swati Sharma |
| RRavjeet SinghRohan | Rohan |
| SSushant GhadgeChotu | Chotu |
 Tripti SahuSurina | Surina |
| GGuneet WahanShamma | Shamma |
 Nazneen MadanDr. Shreya Talpade | Dr. Shreya Talpade |
| VVinayak KetkarCasting Agent | Casting Agent |
| SSubhasis ChakrabortyJyoti’s Colleague 1 | Jyoti’s Colleague 1 |
| SSunita MalhotraKiran’s Mother | Kiran’s Mother |
| TTasneem AliMrs. Sinha | Mrs. Sinha |
| KKashish KanwarNatasha | Natasha |