An American scientist up to no good (as usual) by creating the half-pterodactyl, half-barracuda: Pteracuda. When the creature inevitably escapes, it's up to Sharktopus to stop him.
| Actor | Role |
|---|---|
 Robert CarradineDr. Rico Symes | Dr. Rico Symes |
 Tony EvangelistaRick Hoffman | Rick Hoffman |
 Rib HillisHamilton | Hamilton |
 Conan O'BrienConan O'Brien | Conan O'Brien |
 Katie SavoyLorena Christmas | Lorena Christmas |
 Amanda PhilipsonAdditional Voices | Additional Voices |
 Akari EndoVeronica Vegas | Veronica Vegas |
 Hector ThenHarold Smith | Harold Smith |
| AAndrew E. TillesDr. Lux | Dr. Lux |
| MMario CearaCameraman | Cameraman |
 Alan Nadal PiantiniVasquez | Vasquez |
| HHensy PichardoNot listed | Not listed |