 Will SmithOscar (voice) | Oscar (voice) |
 Robert De NiroDon Lino (voice) | Don Lino (voice) |
 Renée ZellwegerAngie (voice) | Angie (voice) |
 Jack BlackLenny (voice) | Lenny (voice) |
 Angelina JolieLola (voice) | Lola (voice) |
 Ziggy MarleyErnie (voice) | Ernie (voice) |
 Martin ScorseseSykes (voice) | Sykes (voice) |
 David P. SmithCrazy Joe (voice) | Crazy Joe (voice) |
 Doug E. DougBernie (voice) | Bernie (voice) |
 Michael ImperioliFrankie (voice) | Frankie (voice) |
 Vincent PastoreLuca (voice) | Luca (voice) |
 Peter FalkDon Feinberg (voice) | Don Feinberg (voice) |
 Katie CouricKatie Current (voice) | Katie Current (voice) |
 Phil LaMarrPrawn Shop Owner (voice) | Prawn Shop Owner (voice) |
 Shelley MorrisonMrs. Sanchez (voice) | Mrs. Sanchez (voice) |
 David SorenShrimp / Worm / Starfish #1 / Killer Whale #2 (voice) | Shrimp / Worm / Starfish #1 / Killer Whale #2 (voice) |
 Bobb'e J. ThompsonShortie #1 (voice) | Shortie #1 (voice) |
 Kamali MinterShortie #2 (voice) | Shortie #2 (voice) |
| EEmily Lyon SeganShortie #3 (voice) | Shortie #3 (voice) |
 Lenny VenitoGiuseppe / Great White #1 (voice) | Giuseppe / Great White #1 (voice) |
| SSaverio GuerraPontrelli (voice) | Pontrelli (voice) |
 Mark SwiftAnnouncer (voice) | Announcer (voice) |
 James MadioGreat White #2 / Hammerhead (voice) | Great White #2 / Hammerhead (voice) |
 Frank VincentGreat White #3 (voice) | Great White #3 (voice) |
 Joseph SiravoGreat White #5 (voice) | Great White #5 (voice) |
 Steve AltermanMessenger Fish / Tip Fish #2 (voice) | Messenger Fish / Tip Fish #2 (voice) |
 Jenifer LewisMotown Turtle (voice) | Motown Turtle (voice) |
 Sean BishopTip Fish #1 / Great White #4 / Whale / Killer Whale #1 (voice) | Tip Fish #1 / Great White #4 / Whale / Killer Whale #1 (voice) |
 James RyanCashier / Oyster / Clown Whale (voice) | Cashier / Oyster / Clown Whale (voice) |
 Latifa OuaouWhale Wash Co-Worker (voice) | Whale Wash Co-Worker (voice) |
